Localized regulation of the axon shaft during the emergence of collateral branches
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منابع مشابه
Septin-Driven Coordination of Actin and Microtubule Remodeling Regulates the Collateral Branching of Axons
Axon branching is fundamental to the development of the peripheral and central nervous system. Branches that sprout from the axon shaft are termed collateral or interstitial branches. Collateral branching of axons requires the formation of filopodia from actin microfilaments (F-actin) and their engorgement with microtubules (MTs) that splay from the axon shaft. The mechanisms that drive and coo...
متن کاملInterstitial branches develop from active regions of the axon demarcated by the primary growth cone during pausing behaviors.
Interstitial branches arise from the axon shaft, sometimes at great distances behind the primary growth cone. After a waiting period that can last for days after extension of the primary growth cone past the target, branches elongate toward their targets. Delayed interstitial branching is an important but little understood mechanism for target innervation in the developing CNS of vertebrates. O...
متن کاملCommon mechanisms underlying growth cone guidance and axon branching.
During development, growth cones direct growing axons into appropriate targets. However, in some cortical pathways target innervation occurs through the development of collateral branches that extend interstitially from the axon shaft. How do such branches form? Direct observations of living cortical brain slices revealed that growth cones of callosal axons pause for many hours beneath their co...
متن کاملPlexin A3 and Turnout Regulate Motor Axonal Branch Morphogenesis in Zebrafish
During embryogenesis motor axons navigate to their target muscles, where individual motor axons develop complex branch morphologies. The mechanisms that control axonal branching morphogenesis have been studied intensively, yet it still remains unclear when branches begin to form or how branch locations are determined. Live cell imaging of individual zebrafish motor axons reveals that the first ...
متن کاملInteraction between Axons and Specific Populations of Surrounding Cells Is Indispensable for Collateral Formation in the Mammillary System
BACKGROUND An essential phenomenon during brain development is the extension of long collateral branches by axons. How the local cellular environment contributes to the initial sprouting of these branches in specific points of an axonal shaft remains unclear. METHODOLOGY/PRINCIPAL FINDINGS The principal mammillary tract (pm) is a landmark axonal bundle connecting ventral diencephalon to brain...
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عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2015